预览加载中,请您耐心等待几秒...
1/10
2/10
3/10
4/10
5/10
6/10
7/10
8/10
9/10
10/10

亲,该文档总共47页,到这已经超出免费预览范围,如果喜欢就直接下载吧~

如果您无法下载资料,请参考说明:

1、部分资料下载需要金币,请确保您的账户上有足够的金币

2、已购买过的文档,再次下载不重复扣费

3、资料包下载后请先用软件解压,在使用对应软件打开

InterferenceFootprinting“Chromatinisthelastrefugeofscoundrels”AMitoticHumanChromosomeChromatinBasicUnitofChromatinStructure:PolynucleosomeLimitedMicrococcalNulceaseDigestionof ChromatinGeneratesa~200bpLadderH1The30nmChromatinFiberAMitoticHumanChromosomeNuclearScaffold/MatrixTheNucleosome 146bpDNA 2XH3,H4,H2A,H2BIdentities=74/82(90%),Positives=79/82(96%) Query:22ILRDNIQGITKPAIRRLARRGGVKRISGLIYEEVRAVLKSFLESVIRDSVTYTEHAKRKT81 +LRDNIQGITKPAIRRLARRGGVKRISGLIYEERVLKFLE+VIRD+VTYTEHAKRKT Sbjct:21VLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKT80 Query:82VTSLDVVYALKRQGRTLYGFGG103 VT++DVVYALKRQGRTLYGFGG Sbjct:81VTAMDVVYALKRQGRTLYGFGG102MWChromosomalProteinsDomainStructureofHistonesH2BH34helix-bundle4helix-bundleH4H4H4H4HistoneCoreH2BH2BN-term helixN-term helixEnergeticandTopological ConsequencesofDNAWrappingBasepair:Basepair:Basepair:19AreNucleosomes“Positioned?”ImplicationsofTranslationalPositioningN-ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE-H3H4H4H4N-SGRGKGGKGLGKGGAKRHRKVLRDNIQ-H4???The“Linker”HistoneH1/H5HistoneH5reducessaltrequirement forchromatincompactionHelixIII- Majorgroove bindingNTheSolenoidModelforthe30nmFiberThe30nmChromatinFiberCondensins